Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism

Pract Neurol. 2018 Aug;18(4):306-310. doi: 10.1136/practneurol-2017-001771. Epub 2018 Jan 29.

Abstract

A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma.

Keywords: neuroendocrinology; neuroimmunology; paediatric neurology; paediatric neuropathology; tumours.

Publication types

  • Case Reports

MeSH terms

  • Atrophy / etiology
  • Cerebral Cortex / pathology*
  • Cytokines / cerebrospinal fluid
  • Female
  • Germinoma / cerebrospinal fluid
  • Germinoma / complications*
  • Germinoma / diagnostic imaging
  • Humans
  • Hypopituitarism / etiology*
  • Octamer Transcription Factor-3 / metabolism
  • Pituitary Neoplasms / cerebrospinal fluid
  • Pituitary Neoplasms / complications*
  • Pituitary Neoplasms / diagnostic imaging
  • S100 Proteins / metabolism
  • Young Adult

Substances

  • Cytokines
  • Octamer Transcription Factor-3
  • POU5F1 protein, human
  • S100 Proteins