Rationale: Calcifying fibrous tumor (CFT) is a rare benign soft tissue mesenchymal neoplasm. Although the gastrointestinal (GI) tract is the most common predilection site of CFT, the clinicians, even including pathologist, generally consider it as GI stromal tumor (GIST) or other submucosal tumors such as schwannoma and leiomyoma.
Patient concerns: A 55-year-old man presented with complaints of epigastric discomfort and abdominal distention for more than 1 year.
Diagnoses: On the basis of endoscopic and computed tomography examination, preliminary diagnosis was GIST.
Interventions: Endoscopic submucosal dissection (ESD) surgery was performed to remove the gastric mass.
Outcomes: The histopathological examination revealed a gastric CFT.
Lessons: We present a case of gastric CFT, which was misdiagnosed as GIST based on endoscopic and radiologic findings.
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