Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review

Jannice de Queiroz Fernandes; Valthierre Nunes de Lima; João Paulo Bonardi; Osvaldo Magro Filho; Sormani Bento Fernandes Queiroz

doi:10.1007/s12663-016-0988-1

Bone regeneration with recombinant human bone morphogenetic protein 2: a systematic review

J Maxillofac Oral Surg. 2018 Mar;17(1):13-18. doi: 10.1007/s12663-016-0988-1. Epub 2016 Dec 16.

Authors

Jannice de Queiroz Fernandes¹, Valthierre Nunes de Lima², João Paulo Bonardi², Osvaldo Magro Filho², Sormani Bento Fernandes Queiroz¹

Affiliations

¹ Quixadaense Post Graduate School, Rodrigues Junior Street, Number 1034, Quixadá, Ceara CEP 63900-000 Brazil.
² 2Department of Surgery and Clinic Integrated, Araçatuba Dental School-UNESP, José Bonifácio Street, Number 1193, Araçatuba, São Paulo CEP 16015-050 Brazil.

Abstract

Aim: The aim of this work was to perform a systematic literature review on the clinical application of rhBMP-2 in bone reconstruction prior to placing implants.

Materials and methods: A PUBMED search was made about the subject and nine clinical trials were selected according to strict inclusion criteria.

Results: Overall success rates of bone regeneration with rhBMP-2 was 81.4% and success of implants placed was 87.4%. Most frequent adverse events were pain, edema and erythema.

Conclusion: It was concluded that the treatment with rhBMP-2 foi satisfactory in most cases and the placement of dental implants in the bone regenerated with rhBMP-2 is feasible.

Keywords: Bone graft; Bone morphogenetic protein 2; Dental implants; Rehabilitation.

Publication types

Review