3-D Quantitative Dynamic Contrast Ultrasound for Prostate Cancer Localization

Ultrasound Med Biol. 2018 Apr;44(4):807-814. doi: 10.1016/j.ultrasmedbio.2017.12.005. Epub 2018 Feb 12.

Abstract

To investigate quantitative 3-D dynamic contrast-enhanced ultrasound (DCE-US) and, in particular 3-D contrast-ultrasound dispersion imaging (CUDI), for prostate cancer detection and localization, 43 patients referred for 10-12-core systematic biopsy underwent 3-D DCE-US. For each 3-D DCE-US recording, parametric maps of CUDI-based and perfusion-based parameters were computed. The parametric maps were divided in regions, each corresponding to a biopsy core. The obtained parameters were validated per biopsy location and after combining two or more adjacent regions. For CUDI by correlation (r) and for the wash-in time (WIT), a significant difference in parameter values between benign and malignant biopsy cores was found (p < 0.001). In a per-prostate analysis, sensitivity and specificity were 94% and 50% for r, and 53% and 81% for WIT. Based on these results, it can be concluded that quantitative 3-D DCE-US could aid in localizing prostate cancer. Therefore, we recommend follow-up studies to investigate its value for targeting biopsies.

Keywords: 3-D ultrasound; Contrast ultrasound; Core needle biopsy; Dispersion imaging; Dynamic contrast-enhanced ultrasound; Prostate cancer imaging; Quantitative; Systematic biopsy.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biopsy
  • Contrast Media*
  • Evaluation Studies as Topic
  • Humans
  • Image Enhancement / methods*
  • Imaging, Three-Dimensional / methods*
  • Male
  • Middle Aged
  • Prostate / diagnostic imaging
  • Prostate / pathology
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology
  • Sensitivity and Specificity
  • Ultrasonography / methods*

Substances

  • Contrast Media