Legionella Effectors Explored with INSeq: New Functional Insights

Monica Rolando; Carmen Buchrieser

doi:10.1016/j.tim.2018.01.003

Legionella Effectors Explored with INSeq: New Functional Insights

Trends Microbiol. 2018 Mar;26(3):169-170. doi: 10.1016/j.tim.2018.01.003. Epub 2018 Jan 31.

Authors

Monica Rolando¹, Carmen Buchrieser²

Affiliations

¹ Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France; CNRS UMR 3525, Paris, France.
² Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France; CNRS UMR 3525, Paris, France. Electronic address: [email protected].

PMID: 29395730
DOI: 10.1016/j.tim.2018.01.003

Abstract

Legionella pneumophila secretes over 300 effector proteins that manipulate host cells. This multiplicity of effectors hampers the characterization of their individual roles. Shames et al. report a new approach to solve the enigma of Legionella effector function by using INSeq to analyse effector functions in the context of infection.

Keywords: Legionella pneumophila; bacterial effectors; transposon insertion sequencing; virulence factors.

Publication types

Comment

MeSH terms

Bacterial Proteins*
Legionella pneumophila
Legionella*

Substances

Bacterial Proteins