Association study of essential tremor genetic loci in Parkinson's disease

Jay P Ross; Sadaf Mohtashami; Etienne Leveille; Amelie M Johnson; Lan Xiong; Patrick A Dion; Edward Fon; Yves Dauvilliers; Nicolas Dupré; Guy A Rouleau; Ziv Gan-Or

doi:10.1016/j.neurobiolaging.2018.01.001

Association study of essential tremor genetic loci in Parkinson's disease

Neurobiol Aging. 2018 Jun:66:178.e13-178.e15. doi: 10.1016/j.neurobiolaging.2018.01.001. Epub 2018 Jan 6.

Authors

Jay P Ross¹, Sadaf Mohtashami², Etienne Leveille³, Amelie M Johnson⁴, Lan Xiong⁵, Patrick A Dion⁶, Edward Fon², Yves Dauvilliers⁷, Nicolas Dupré⁸, Guy A Rouleau⁹, Ziv Gan-Or¹⁰

Affiliations

¹ Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada.
² Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Experimental Medicine, McGill University, Montréal, Quebec, Canada.
³ Faculty of Medicine, McGill University, Montréal, Quebec, Canada.
⁴ Laboratoire de neurogénétique, Centre de recherche, Institut universitaire en santé mentale de Montréal, Montréal, Quebec, Canada.
⁵ Laboratoire de neurogénétique, Centre de recherche, Institut universitaire en santé mentale de Montréal, Montréal, Quebec, Canada; Département de psychiatrie, Université de Montréal, Montréal, Quebec, Canada.
⁶ Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
⁷ National Reference Center for Narcolepsy, Sleep Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, University of Montpellier, Inserm U1061, Montpellier, France.
⁸ Division of Neurosciences, CHU de Québec, Université Laval, Quebec City, Quebec, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, Quebec, Canada.
⁹ Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
¹⁰ Department of Human Genetics, McGill University, Montréal, Quebec, Canada; Montreal Neurological Institute, McGill University, Montréal, Quebec, Canada; Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada. Electronic address: [email protected].

PMID: 29398123
DOI: 10.1016/j.neurobiolaging.2018.01.001

Abstract

A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the present study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.

Keywords: Essential tremor; GWAS; Parkinson's disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Canada
Cohort Studies
Essential Tremor / genetics*
Female
France
Genes, Overlapping / genetics*
Genetic Loci / genetics*
Genome-Wide Association Study*
Genomic Structural Variation / genetics*
Genotype
Humans
Logistic Models
Male
Middle Aged
Parkinson Disease / genetics*