New penicillide derivatives isolated from Penicillium simplicissimum

Shin-Ichirou Komai; Tomoo Hosoe; Takeshi Itabashi; Koohei Nozawa; Takashi Yaguchi; Kazutaka Fukushima; Ken-Ichi Kawai

doi:10.1007/s11418-005-0028-9

New penicillide derivatives isolated from Penicillium simplicissimum

J Nat Med. 2006 Jul;60(3):185-190. doi: 10.1007/s11418-005-0028-9. Epub 2006 Apr 14.

Authors

Shin-Ichirou Komai¹, Tomoo Hosoe¹, Takeshi Itabashi¹, Koohei Nozawa², Takashi Yaguchi³, Kazutaka Fukushima³, Ken-Ichi Kawai⁴

Affiliations

¹ Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
² School of Pharmaceutical Sciences, Ohu University, 31-1 Misumido, Tomita-machi, Koriyama, Fukushima 963-8611, Japan.
³ Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Chuo-ku, Chiba 260-8673, Japan.
⁴ Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan. [email protected].

PMID: 29435879
DOI: 10.1007/s11418-005-0028-9

Abstract

Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.

Keywords: Antifungal activity; Penicillide; Penicillium simplicissimum; Purpactin A; Secopenicillide A; Secopenicillide B.