Transformation of chronic lymphocytic leukemia into B-cell acute lymphoblastic leukemia

Blood. 2018 Mar 15;131(11):1258-1261. doi: 10.1182/blood-2017-11-819276. Epub 2018 Feb 5.

Authors

Seongseok Yun¹, Ling Zhang², Manish R Patel³, Todd C Knepper⁴, Julio C Chavez¹, Javier Pinilla-Ibarz¹

Affiliations

¹ Department of Malignant Hematology and.
² Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.
³ Florida Cancer Specialists & Sarah Cannon Research Institute, Sarasota, FL; and.
⁴ DeBartolo Family Personalized Medicine Institute, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL.

PMID: 29437555
DOI: 10.1182/blood-2017-11-819276

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Aged
Cell Transformation, Neoplastic* / genetics
Cell Transformation, Neoplastic* / metabolism
Cell Transformation, Neoplastic* / pathology
Humans
Isoquinolines / administration & dosage*
Leukemia, Lymphocytic, Chronic, B-Cell* / drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
Male
Mutation*
Neoplasm Proteins* / genetics
Neoplasm Proteins* / metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / metabolism
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology
Purines / administration & dosage*

Substances

Isoquinolines
Neoplasm Proteins
Purines
duvelisib