Clinical outcome of concomitant vs interrupted BRAF inhibitor therapy during radiotherapy in melanoma patients

Markus Hecht; Friedegund Meier; Lisa Zimmer; Bülent Polat; Carmen Loquai; Carsten Weishaupt; Andrea Forschner; Ralf Gutzmer; Jochen S Utikal; Simone M Goldinger; Michael Geier; Jessica C Hassel; Panagiotis Balermpas; Felix Kiecker; Ricarda Rauschenberg; Ursula Dietrich; Patrick Clemens; Carola Berking; Gerhard Grabenbauer; Dirk Schadendorf; Stephan Grabbe; Gerold Schuler; Rainer Fietkau; Luitpold V Distel; Lucie Heinzerling

doi:10.1038/bjc.2017.489

Clinical outcome of concomitant vs interrupted BRAF inhibitor therapy during radiotherapy in melanoma patients

Br J Cancer. 2018 Mar 20;118(6):785-792. doi: 10.1038/bjc.2017.489. Epub 2018 Feb 13.

Authors

Markus Hecht¹, Friedegund Meier², Lisa Zimmer³, Bülent Polat⁴, Carmen Loquai⁵, Carsten Weishaupt⁶, Andrea Forschner⁷, Ralf Gutzmer⁸, Jochen S Utikal^{9

10}, Simone M Goldinger¹¹, Michael Geier¹², Jessica C Hassel¹³, Panagiotis Balermpas¹⁴, Felix Kiecker¹⁵, Ricarda Rauschenberg², Ursula Dietrich², Patrick Clemens¹⁶, Carola Berking¹⁷, Gerhard Grabenbauer¹⁸, Dirk Schadendorf³, Stephan Grabbe⁵, Gerold Schuler¹⁹, Rainer Fietkau¹, Luitpold V Distel¹, Lucie Heinzerling¹⁹

Affiliations

¹ Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany.
² Department of Dermatology, University Hospital Dresden, Dresden, Germany.
³ Department of Dermatology, University Hospital Essen, Essen, Germany.
⁴ Department of Radiation Oncology, University Hospital Würzburg, Würzburg, Germany.
⁵ Department of Dermatology, University Medical Center Mainz, Mainz, Germany.
⁶ Department of Dermatology, University Hospital Münster, Münster, Germany.
⁷ Department of Dermatology, University Hospital Tübingen, Tübingen, Germany.
⁸ Skin Cancer Center Hannover, Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
⁹ Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁰ Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, Ruprecht-Karl University of Heidelberg, Mannheim, Germany.
¹¹ Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.
¹² Department of Radiation Oncology, Ordensklinikum Linz, Linz, Austria.
¹³ Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany.
¹⁴ Department of Radiation Oncology, University Hospital Frankfurt, Frankfurt, Germany.
¹⁵ Department of Dermatology, University Hospital Berlin, Berlin, Germany.
¹⁶ Department of Radiation Oncology, Hospital Feldkirch, Feldkirch, Austria.
¹⁷ Department of Dermatology, University Hospital LMU Munich, München, Germany.
¹⁸ Department of Radiation Oncology, Hospital Coburg, Coburg, Germany.
¹⁹ Department of Dermatology, University Hospital Erlangen, Erlangen, Germany.

Abstract

This corrects the article DOI: 10.1038/bjc.2017.85.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cohort Studies
Drug Administration Schedule
Female
Humans
Imidazoles / administration & dosage
Male
Melanoma / drug therapy*
Melanoma / enzymology
Melanoma / radiotherapy*
Middle Aged
Oximes / administration & dosage
Protein Kinase Inhibitors / administration & dosage
Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
Radiation-Sensitizing Agents / administration & dosage
Retrospective Studies
Skin Neoplasms / drug therapy*
Skin Neoplasms / enzymology
Skin Neoplasms / radiotherapy*
Treatment Outcome
Vemurafenib / administration & dosage
Young Adult

Substances

Imidazoles
Oximes
Protein Kinase Inhibitors
Radiation-Sensitizing Agents
Vemurafenib
BRAF protein, human
Proto-Oncogene Proteins B-raf
dabrafenib