A Proof-of-Concept Study of the Efficacy of Systemically Administered Polymyxins in Mouse Burn Wound Infection Caused by Multidrug-Resistant Gram-Negative Pathogens

Antimicrob Agents Chemother. 2018 Apr 26;62(5):e02527-17. doi: 10.1128/AAC.02527-17. Print 2018 May.

Abstract

The efficacy of subcutaneously administered polymyxins against burn wound infections caused by Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B (30 mg/kg thrice daily) achieved a ≥2-log10 reduction in the bacterial load for P. aeruginosa and A. baumannii infections, whereas wound infections by K. pneumoniae were less responsive (<1-log10 reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections.

Keywords: Acinetobacter baumannii; Klebsiella pneumoniae; Pseudomonas aeruginosa; multidrug resistance; polymyxins; thermal injury.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Burns / microbiology*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / pathogenicity
  • Mice
  • Microbial Sensitivity Tests
  • Polymyxins / therapeutic use*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / pathogenicity

Substances

  • Anti-Bacterial Agents
  • Polymyxins