Abstract
Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Culture Media / chemistry
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Fructosephosphates / metabolism
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Fructosephosphates / toxicity*
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Galactosephosphates / metabolism
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Galactosephosphates / toxicity*
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Gene Expression Regulation, Fungal
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Genes, Fungal
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Genes, Suppressor*
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Mutation
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism*
Substances
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Culture Media
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Fructosephosphates
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Galactosephosphates
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fructose-1-phosphate
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galactose-1-phosphate