Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome

Carla Bellomo; Miša Korva; Anna Papa; Satu Mäkelä; Jukka Mustonen; Tatjana Avšič-Županc; Antti Vaheri; Valeria P Martinez; Tomas Strandin

doi:10.1093/ofid/ofy021

Differential Regulation of PAI-1 in Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever With Renal Syndrome

Open Forum Infect Dis. 2018 Jan 17;5(2):ofy021. doi: 10.1093/ofid/ofy021. eCollection 2018 Feb.

Authors

Carla Bellomo¹, Miša Korva², Anna Papa³, Satu Mäkelä⁴, Jukka Mustonen⁴, Tatjana Avšič-Županc², Antti Vaheri⁵, Valeria P Martinez¹, Tomas Strandin⁵

Affiliations

¹ Laboratorio Nacional de Referencia para Hantavirus, Servicio Biología Molecular, Departamento Virología-INEI-ANLIS "Dr C. G. Malbrán," Buenos Aires, Argentina.
² Institute of Microbiology and Immunology, Faculty of Medicine University of Ljubljana, Ljubljana, Slovenia.
³ Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
⁴ Department of Internal Medicine, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finl.
⁵ Department of Virology, Medicum, Faculty of Medicine, University of Helsinki, Helsinki, Finl.

Abstract

We analyzed the levels of circulating tissue plasminogen activator (tPA) and plasminogen activator inhibitor (PAI)-1 in acute hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS). The levels of tPA commonly increased in both diseases, whereas PAI-1 correlated with disease severity in HCPS but not in HFRS.

Keywords: HCPS; HFRS; PAI-1; hantavirus; tPA.