Inflammation NODs to Antagonists of RIP2-XIAP Interaction

Shiyu Xia; Tian-Min Fu; Hao Wu

doi:10.1016/j.molcel.2018.02.003

Inflammation NODs to Antagonists of RIP2-XIAP Interaction

Mol Cell. 2018 Feb 15;69(4):535-536. doi: 10.1016/j.molcel.2018.02.003.

Authors

Shiyu Xia¹, Tian-Min Fu¹, Hao Wu²

Affiliations

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.
² Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Electronic address: [email protected].

Abstract

While innate immunity is crucial for host defense, dysregulated signaling activation leads to pathological inflammation. In this issue of Molecular Cell, Goncharov et al. (2018) present a strategy to combat inflammatory diseases by disrupting RIP2-XIAP interaction in NOD2-mediated signaling.

Publication types

Comment

MeSH terms

Humans
Immunity, Innate
Inflammation
Nod2 Signaling Adaptor Protein*
Receptor-Interacting Protein Serine-Threonine Kinase 2*
Signal Transduction
X-Linked Inhibitor of Apoptosis Protein

Substances

NOD2 protein, human
Nod2 Signaling Adaptor Protein
X-Linked Inhibitor of Apoptosis Protein
XIAP protein, human
Receptor-Interacting Protein Serine-Threonine Kinase 2

Abstract

Publication types

MeSH terms

Substances

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