T Cell LEGO: Identifying the Master Builders and What They Do

Jasmine Li; Stephen J Turner

doi:10.1016/j.immuni.2018.02.004

T Cell LEGO: Identifying the Master Builders and What They Do

Immunity. 2018 Feb 20;48(2):185-187. doi: 10.1016/j.immuni.2018.02.004.

Authors

Jasmine Li¹, Stephen J Turner²

Affiliations

¹ Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
² Department of Microbiology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. Electronic address: [email protected].

PMID: 29466746
DOI: 10.1016/j.immuni.2018.02.004

Abstract

Understanding how cell fate decisions are made during cellular differentiation and the mechanisms that drive them is a holy grail of cell biology. In this issue of Immunity, Hu et al. (2018) and Johnson et al. (2018) demonstrate that key transcriptional regulators and global changes in nuclear architecture underlie differentiation decisions during T cell development.

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MeSH terms

Cell Differentiation*
T-Lymphocytes*