Evaluation of the long-term efficacy of K-Othrine® PolyZone on three surfaces against laboratory reared Anopheles gambiae in semi-field conditions

Malar J. 2018 Feb 23;17(1):94. doi: 10.1186/s12936-018-2239-z.

Abstract

Background: In this semi-field study, a new polymer-enhanced deltamethrin formulation, K-Othrine® PolyZone, was compared to a standard deltamethrin product for residual activity against a susceptible strain of laboratory-reared Anopheles gambiae using standard WHO cone bioassays.

Methods: Residual insecticide efficacy was recorded after exposure to metal, cement and wood panels maintained in experimental huts in sub-tropical environmental conditions in north central Florida, USA, and panels stored in a climate controlled chamber located at the Centers for Disease Control and Prevention, Georgia, USA.

Conclusions: K-Othrine® PolyZone demonstrated 100% control on metal and cement panels 1 year post application and > 80% control on wood panels up to 6 mo. The new formulation should be considered for use in indoor residual spray programmes requiring long-term control of malaria vectors.

Keywords: Anopheles gambiae; Deltamethrin; Experimental huts; Indoor residual spray; K-Othrine PolyZone.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anopheles / drug effects*
  • Anopheles / growth & development*
  • Biological Assay
  • Construction Materials*
  • Drug Interactions
  • Florida
  • Georgia
  • Insecticides / pharmacology*
  • Nitriles / pharmacology*
  • Pyrethrins / pharmacology*
  • Survival Analysis

Substances

  • Insecticides
  • Nitriles
  • Pyrethrins
  • decamethrin