Physiological functions of FBW7 in cancer and metabolism

Cell Signal. 2018 Jun:46:15-22. doi: 10.1016/j.cellsig.2018.02.009. Epub 2018 Feb 21.

Abstract

FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCFFBW7 plays key roles in regulating cell cycle progression, differentiation, and stem cell maintenance largely through targeting a broad range of oncogenic substrates for proteasome-dependent degradation. The identification of an increasing number of FBW7 substrates for ubiquitination, and intensive in vitro and in vivo studies have revealed a network of signaling components controlled by FBW7 that contributes to metabolic regulation as well as its tumor suppressor role. Here we mainly focus on recent findings that highlight a critical role for FBW7 in cancer and metabolism.

Keywords: FBW7; Metabolism; SCF complex; Stem cell; Tumor suppressor; Ubiquitination.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle
  • Cell Differentiation
  • Cell Line, Tumor
  • F-Box-WD Repeat-Containing Protein 7 / genetics
  • F-Box-WD Repeat-Containing Protein 7 / physiology*
  • Humans
  • Mice
  • Neoplasms / metabolism*
  • Phosphorylation
  • Signal Transduction
  • Tumor Suppressor Proteins / physiology
  • Ubiquitination*

Substances

  • F-Box-WD Repeat-Containing Protein 7
  • Tumor Suppressor Proteins