Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in Stereotactic Body Radiation Therapy for Locally Recurrent Previously-Irradiated Head and Neck Cancer: Report of the AAPM Working Group

John A Vargo; Vitali Moiseenko; Jimm Grimm; Jimmy Caudell; David A Clump; Ellen Yorke; Jinyu Xue; Yevgeniy Vinogradskiy; Eduardo G Moros; Panayiotis Mavroidis; Sheena Jain; Issam El Naqa; Lawrence B Marks; Dwight E Heron

doi:10.1016/j.ijrobp.2018.01.044

Head and Neck Tumor Control Probability: Radiation Dose-Volume Effects in Stereotactic Body Radiation Therapy for Locally Recurrent Previously-Irradiated Head and Neck Cancer: Report of the AAPM Working Group

Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):137-146. doi: 10.1016/j.ijrobp.2018.01.044. Epub 2018 Jan 31.

Authors

Affiliations

¹ Department of Radiation Oncology, West Virginia University, Morgantown, West Virginia.
² Radiation Medicine & Applied Sciences, University of California, San Diego, La Jolla, California.
³ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland.
⁴ H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
⁵ Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
⁶ Memorial Sloan Kettering Cancer Center, New York, New York.
⁷ Department of Radiation Oncology, M. D. Anderson Cancer Center at Cooper University Hospital, Camden, New Jersey.
⁸ Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
⁹ Department of Radiation Oncology and Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
¹⁰ Bott Cancer Center, Holy Redeemer Hospital, Meadowbrook, Pennsylvania.
¹¹ University of Michigan, Ann Arbor, Michigan.
¹² Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. Electronic address: [email protected].

Abstract

Purpose: Stereotactic body radiation therapy (SBRT) has emerged as a viable reirradiation strategy for locally recurrent previously-irradiated head and neck cancer. Doses in the literature have varied, which challenges clinical application of SBRT as well as clinical trial design.

Material & methods: A working group was formed through the American Association of Physicists in Medicine to study tumor control probabilities for SBRT in head and neck cancer. We herein present a systematic review of the available literature addressing the dose/volume data for tumor control probability with SBRT in patients with locally recurrent previously-irradiated head and neck cancer. Dose-response models are generated that present tumor control probability as a function of dose.

Results: Data from more than 300 cases in 8 publications suggest that there is a dose-response relationship, with superior local control and possibly improved overall survival for doses of 35 to 45 Gy (in 5 fractions) compared with <30 Gy.

Conclusion: Stereotactic body radiation therapy doses equivalent to 5-fraction doses of 40 to 50 Gy are suggested for retreatment.

Publication types

Research Support, N.I.H., Extramural
Systematic Review

MeSH terms

Dose-Response Relationship, Radiation
Head and Neck Neoplasms / diagnostic imaging
Head and Neck Neoplasms / mortality
Head and Neck Neoplasms / radiotherapy*
Humans
Models, Biological
Models, Theoretical
Neoplasm Recurrence, Local / radiotherapy*
Probability
Radiotherapy Dosage
Re-Irradiation
Treatment Failure

Abstract

Publication types

MeSH terms

Grants and funding