Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency

Affiliations

• ¹ Leeds Institute of Biomedical and Clinical Sciences, University of Leeds, St James's University Hospital, Leeds, United Kingdom.
• ² Immunology Outpatient Clinic, Vienna, Austria.
• ³ Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
• ⁴ NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.
• ⁵ School of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
• ⁶ Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.
• ⁷ Division of Hematology, Children's Hospital Orange County, Orange, Calif.
• ⁸ Department of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom; Institute of Immunity and Transplantation, University College London, London, United Kingdom.
• ⁹ Department of Pediatrics, Division of Pediatric Allergy Immunology, University of California Los Angeles, Calif.
• ¹⁰ University of South Florida and Johns Hopkins All Children's Hospital, Saint Petersburg, Fla.
• ¹¹ Clinical Immunology and Allergy Unit, Sheffield Teaching Hospitals, Sheffield, United Kingdom.
• ¹² Center for Chronic Immunodeficiency, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.
• ¹³ Immunology Outpatient Clinic, Vienna, Austria; Biomedizinische Forschungs GmbH, Vienna, Austria.
• ¹⁴ Division of Pulmonary, Allergy and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pa.
• ¹⁵ Oslo University Hospital Radiumhospitalet, Department of Cancer Immunology, Institute for Cancer Research, Oslo, Norway.
• ¹⁶ Division of Pediatric Pulmonary, Johns Hopkins All Children's Hospital, St Petersburg, Fla.
• ¹⁷ Department of Pediatrics, Allergy Immunology Division, the Children's Hospital of Philadelphia and Institute for Immunology, University of Pennsylvania, Philadelphia, Pa.
• ¹⁸ the Laboratory of Clinical Immunology and Microbiology, LCIM, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
• ¹⁹ Division of Hematology/Oncology CHOC Children's Hospital, Orange, Calif.
• ²⁰ Department of Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School, Hannover, Germany.
• ²¹ Department of Pediatric Hematology, Immunology and Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands; Department of Blood Cell Research, Sanquin Research and Landsteiner Laboratory at the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
• ²² Department of Immunology, Royal Free London NHS Foundation Trust, London, United Kingdom.
• ²³ Department of Pediatrics, Division of Allergy and Clinical Immunology, Yale University School of Medicine, New Haven, Conn.
• ²⁴ Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
• ²⁵ Research Department, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Minsk Region, Minsk, Belarus.
• ²⁶ Department of Medicine, University of Cambridge, Cambridge, United Kingdom.
• ²⁷ NIHR BioResource, Cambridge University Hospitals, Cambridge Biomedical Campus, Cambridge, United Kingdom; Center for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.
• ²⁸ Molecular and Cellular Immunology Section, Great Ormond Street Institute of Child Health and Great Ormond Street Hospital NHS Trust, London, United Kingdom.
• ²⁹ Immunology Outpatient Clinic, Vienna, Austria; Sigmund Freud Private University- Medical School, Vienna, Austria.
• ³⁰ University of South Florida and Johns Hopkins All Children's Hospital, Saint Petersburg, Fla; Division of Allergy Immunology, Massachusetts General Hospital for Children, Boston, Mass. Electronic address: [email protected].
• ³¹ Department of Clinical Immunology and Allergy, St James's University Hospital, Leeds, United Kingdom; National Institute for Health Research-Leeds Musculoskeletal Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, United Kingdom. Electronic address: [email protected].