Giant Condylomata Acuminata of Buschke-Lowenstein Associated With Paraneoplastic Hypercalcemia

Fredrick Venter; Arash Heidari; Macsen Viehweg; Mark Rivera; Piruthiviraj Natarajan; Everardo Cobos

doi:10.1177/2324709618758348

Giant Condylomata Acuminata of Buschke-Lowenstein Associated With Paraneoplastic Hypercalcemia

J Investig Med High Impact Case Rep. 2018 Feb 15:6:2324709618758348. doi: 10.1177/2324709618758348. eCollection 2018 Jan-Dec.

Authors

Fredrick Venter¹, Arash Heidari¹, Macsen Viehweg¹, Mark Rivera¹, Piruthiviraj Natarajan¹, Everardo Cobos¹

Affiliation

¹ Kern Medical Center, Bakersfield, CA, USA.

Abstract

Low-risk human papillomavirus types 6 and 11 can manifest as giant condylomata acuminata (GCA) of Buschke-Lowenstein. Up to 50% of GCA can slowly progress over years to fungating, invasive tumors. The malignant potential is attributed to unique immune evading abilities of the human papillomavirus. A 42-year-old male presented with pain and foul-smelling discharge from his genital warts. The histopathological examination of the mass showed invasive squamous cell carcinoma, and it was associated with paraneoplastic hypercalcemia. The timely removal of long-standing GCA in order to prevent a carcinomatous transition is a priority.

Keywords: Buschke Lowenstein tumor; E6 and E7 oncogenes; HPV vaccination; genital warts; giant condylomata acuminata; human papillomavirus; paraneoplastic hypercalcemia; squamous cell carcinoma.