Abstract
A trans-DDP based monofunctional phenanthridine Pt(ii) complex was synthesized and characterized. Its anticancer activity was studied in vitro on a panel of human cancer cell lines and mouse intestinal cancer organoids. This complex displays significant antitumor properties, with a different spectrum of activity than that of classic bifunctional cross-linking agents like cisplatin.
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Isomerism
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Models, Molecular
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Molecular Structure
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry*
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Organoplatinum Compounds / pharmacology*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Organoplatinum Compounds