A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function

PLoS Pathog. 2018 Mar 5;14(3):e1006806. doi: 10.1371/journal.ppat.1006806. eCollection 2018 Mar.

Abstract

ClinicalTrials.gov Clinical Trial NCT00594880.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Antiretroviral Therapy, Highly Active*
  • Epithelial Cells / drug effects
  • Epithelial Cells / metabolism*
  • Epithelial Cells / virology
  • Female
  • HIV Infections / drug therapy
  • HIV Infections / metabolism*
  • HIV Infections / virology
  • HIV-1 / drug effects
  • HIV-1 / physiology*
  • Humans
  • Intestinal Mucosa / metabolism*
  • Intestines / drug effects
  • Intestines / virology
  • Male
  • Mice
  • Middle Aged
  • Tumor Necrosis Factor alpha-Induced Protein 3 / genetics
  • Tumor Necrosis Factor alpha-Induced Protein 3 / metabolism*
  • Viral Load

Substances

  • TNFAIP3 protein, human
  • Tumor Necrosis Factor alpha-Induced Protein 3

Associated data

  • ClinicalTrials.gov/NCT00594880