Improved overall survival in head and neck cancer patients after specific therapy of distant metastases

Eur Arch Otorhinolaryngol. 2018 May;275(5):1239-1247. doi: 10.1007/s00405-018-4920-9. Epub 2018 Mar 8.

Abstract

Purpose: While metastases directed therapy for oligometastatic disease is recommended in different cancer entities, the treatment of solitary metastases in head and neck squamous cell carcinoma (HNSCC) patients is not clearly defined.

Methods: A retrospective analysis was performed on data from 143 HNSCC patients treated between 2001 and 2016 in a tertiary university hospital. Clinical factors and outcome were measured using the median survival of patients receiving metastases specific therapy in comparison with matched control patients.

Results: In 37 patients, distant metastases were treated specifically with either surgery and/or stereotactic ablative radiotherapy and had with 23.97 months a more than three times higher median survival than 10 untreated matched controls with potentially treatable distant metastases (7.07 months).

Conclusions: Our retrospective analysis demonstrates a significant survival benefit for HNSCC patients who received a specific therapy regarding distant metastasis irrespective of localization as compared to a matched control cohort.

Keywords: Distant metastases; HNSCC; Overall survival; Radiotherapy; Specific treatment.

MeSH terms

  • Adult
  • Aged
  • Carcinoma, Squamous Cell* / mortality
  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / therapy
  • Female
  • Germany / epidemiology
  • Head and Neck Neoplasms* / mortality
  • Head and Neck Neoplasms* / pathology
  • Head and Neck Neoplasms* / therapy
  • Humans
  • Male
  • Middle Aged
  • Neck Dissection / methods*
  • Neoplasm Metastasis / pathology
  • Neoplasm Metastasis / therapy
  • Neoplasm Staging
  • Outcome and Process Assessment, Health Care
  • Radiosurgery / methods*
  • Retrospective Studies
  • Squamous Cell Carcinoma of Head and Neck
  • Survival Analysis