Biological imaging for individualized therapy in radiation oncology: part II medical and clinical aspects

Eleni Gkika; Oliver Oehlke; Hatice Bunea; Nicole Wiedenmann; Sonja Adebahr; Ursula Nestle; Constantinos Zamboglou; Simon Kirste; Jamina Fennell; Thomas Brunner; Mark Gainey; Dimos Baltas; Mathias Langer; Horst Urbach; Michael Bock; Philipp T Meyer; Anca-Ligia Grosu

doi:10.2217/fon-2017-0465

Biological imaging for individualized therapy in radiation oncology: part II medical and clinical aspects

Future Oncol. 2018 Apr;14(8):751-769. doi: 10.2217/fon-2017-0465. Epub 2018 Mar 9.

Authors

Eleni Gkika^{1

2}, Oliver Oehlke^{1

2}, Hatice Bunea^{1

2}, Nicole Wiedenmann^{1

2}, Sonja Adebahr^{1

2}, Ursula Nestle^{1

2}, Constantinos Zamboglou^{1

2}, Simon Kirste^{1

2}, Jamina Fennell^{1

2}, Thomas Brunner^{1

2}, Mark Gainey^{1

2}, Dimos Baltas^{1

2}, Mathias Langer³, Horst Urbach⁴, Michael Bock⁵, Philipp T Meyer^{2

6}, Anca-Ligia Grosu^{1

2}

Affiliations

¹ Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, D-79106, Germany.
² German Cancer Consortium (DKTK), Partner Site Freiburg, German Cancer Research Center (DKFZ), Heidelberg, D-69120, Germany.
³ Department of Radiology, Medical Center, Faculty of Medicine, University of Freiburg, D-79106, Germany.
⁴ Department of Neuroradiology, Medical Center, Faculty of Medicine, University of Freiburg, D-79106, Germany.
⁵ Department of Radiology - Medical Physics, Department of Radiology, Faculty of Medicine, Medical Center, University of Freiburg, D-79106, Germany.
⁶ Department of Nuclear Medicine, Medical Center, Faculty of Medicine, University of Freiburg, D-79106, Germany.

PMID: 29521519
DOI: 10.2217/fon-2017-0465

Abstract

Positron emission tomography and multiparametric MRI provide crucial information concerning tumor extent and normal tissue anatomy. Moreover, they are able to visualize biological characteristics of the tumor, which can be considered in the radiation treatment planning and monitoring. In this review we discuss the impact of biological imaging positron emission tomography and multiparametric MRI for radiation oncology, based on the data of the literature and on the experience of our own institution in this field.

Keywords: FDG-PET; FET-PET; FMISO-PET; MET-PET; MR spectroscopy; MR-PET/CT; PSMA-PET-CT; diffusion-weighted MRI; functional imaging; tumor delineation.

MeSH terms

Contrast Media / therapeutic use
Diffusion Magnetic Resonance Imaging
Humans
Neoplasms / diagnostic imaging*
Neoplasms / pathology
Neoplasms / radiotherapy*
Positron Emission Tomography Computed Tomography
Precision Medicine*
Radiation Oncology / methods
Radiation Oncology / trends*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Tomography, X-Ray Computed

Substances

Contrast Media