Zidovudine protects hyperosmolarity-stressed human corneal epithelial cells via antioxidant pathway

Biochem Biophys Res Commun. 2018 May 5;499(2):177-181. doi: 10.1016/j.bbrc.2018.03.112. Epub 2018 Mar 24.

Abstract

Dry Eye Disease (DED) is a very common disorder that can result in severe disability and vision loss. Although the pathogenesis of DED is not fully understood, hyperosmolarity, inflammation, and tear film instability are recognized as hallmarks of DED. Recently, Nucleoside Reverse Transcriptase Inhibitors (NRTIs), a class of medication used to treat HIV, have been shown to inhibit inflammation in a mouse model of retinal atrophy. In this study, we investigated whether Zidovudine (AZT) can inhibit human corneal epithelial cell (HCEC) inflammatory responses under hyperosmotic conditions. HCECs were cultured in hyperosmotic media containing AZT. Cell viability, cytokine production, and reactive oxygen species (ROS) production were measured. We found that AZT decreased nuclear factor kappa B (NF-κB) and Interleukin-6 (IL-6) levels, increased Superoxide Dismutase 1 (SOD1) production, decreased ROS production, and increased cell viability. These results support the novel use of AZT in the reduction of ocular surface inflammation and the promotion of corneal health in the context of DED.

Keywords: Azidothymidine (AZT); Dry eye disease (DED); Human corneal epithelial cell (HCEC); Inflammation; Nucleoside reverse transcriptase inhibitor (NRTI); Reactive oxygen species (ROS); Zidovudine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / metabolism*
  • Cell Line
  • Cell Survival / drug effects
  • Cornea / pathology*
  • Cytokines / biosynthesis
  • Cytoprotection / drug effects*
  • Epithelial Cells / drug effects
  • Epithelial Cells / metabolism*
  • Epithelial Cells / pathology*
  • Humans
  • Inflammation Mediators / metabolism
  • NF-kappa B / metabolism
  • Osmolar Concentration
  • Reactive Oxygen Species / metabolism
  • Sodium Chloride / pharmacology
  • Stress, Physiological* / drug effects
  • Superoxide Dismutase-1 / metabolism
  • Zidovudine / pharmacology*

Substances

  • Antioxidants
  • Cytokines
  • Inflammation Mediators
  • NF-kappa B
  • Reactive Oxygen Species
  • Sodium Chloride
  • Zidovudine
  • Superoxide Dismutase-1