Imaging the myocardial ischemic cascade

Int J Cardiovasc Imaging. 2018 Aug;34(8):1249-1263. doi: 10.1007/s10554-018-1330-4. Epub 2018 Mar 19.

Abstract

Non-invasive imaging plays a growing role in the diagnosis and management of ischemic heart disease from its earliest manifestations of endothelial dysfunction to myocardial infarction along the myocardial ischemic cascade. Experts representing the North American Society for Cardiovascular Imaging and the European Society of Cardiac Radiology have worked together to organize the role of non-invasive imaging along the framework of the ischemic cascade. The current status of non-invasive imaging for ischemic heart disease is reviewed along with the role of imaging for guiding surgical planning. The issue of cost effectiveness is also considered. Preclinical disease is primarily assessed through the coronary artery calcium score and used for risk assessment. Once the patient becomes symptomatic, other imaging tests including echocardiography, CCTA, SPECT, PET and CMR may be useful. CCTA appears to be a cost-effective gatekeeper. Post infarction CMR and PET are the preferred modalities. Imaging is increasingly used for surgical planning of patients who may require coronary artery bypass.

Keywords: Cardiac imaging; Coronary artery disease; Ischemic heart disease.

Publication types

  • Review

MeSH terms

  • Angina Pectoris / diagnostic imaging
  • Cardiac Imaging Techniques / economics
  • Cardiac Imaging Techniques / methods*
  • Coronary Artery Disease / complications
  • Coronary Artery Disease / diagnostic imaging*
  • Coronary Artery Disease / surgery
  • Cost-Benefit Analysis
  • Disease Progression
  • Endothelium, Vascular / diagnostic imaging
  • Humans
  • Myocardial Infarction / diagnostic imaging
  • Myocardial Infarction / etiology
  • Myocardial Ischemia / diagnostic imaging*
  • Myocardial Ischemia / etiology