Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from 23Na-MRI

J Neurol Sci. 2018 Apr 15:387:111-114. doi: 10.1016/j.jns.2018.01.027. Epub 2018 Feb 6.

Abstract

Sodium MRI (23Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution 23Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using 23Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0.01), as well as a heterogeneous distribution of both the total tissue sodium concentration and the intracellular-weighted sodium concentration.

Keywords: (23)Na; 3-tesla; Extracellular sodium; High-resolution; Intracellular sodium; Multiple sclerosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Analysis of Variance
  • Brain / diagnostic imaging*
  • Brain / drug effects
  • Disability Evaluation
  • Female
  • Humans
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging*
  • Multiple Sclerosis / diagnostic imaging*
  • Multiple Sclerosis / metabolism*
  • Sodium / metabolism*
  • Sodium Radioisotopes / pharmacokinetics

Substances

  • Sodium Radioisotopes
  • Sodium