A case of dystrophic calcification of the myocardium in the transplanted heart of a 34-year-old man is presented. The calcification appeared immediately after transplantation with massive progression until the thirty-fifth day when the patient died. Pulmonary hypertension, cardiac surgery, administration of steroids and calcium chloride, in addition to transitory acute renal failure may be the multicausal factors that produced this myocardial calcification.