The infiltration by numerous osteoclastic giant cells is a frequent finding in bone tumors and pseudo-tumors. Pathologists must integrate clinical and radiological data to achieve a correct diagnosis in bone pathology. Benign giant-cell rich lesions of bone encompass giant cell tumor of bone, aneurysmal bone cyst, chondroblastoma, brown tumor and fibrous cortical defect/non-ossifying fibroma. Amongst malignant neoplasms, variants of conventional osteosarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma and bone metastasis must be discussed. Recently, new diagnostic markers, antibodies for immuno-histochemistry and genetic markers, have been developed and are helpful to diagnose such lesions.
Keywords: Aneurysmal bone cyst; Brown tumor; Cellules géantes; Chondroblastoma; Chondroblastome; Cortical defect; Fibrome ossifiant; Giant cell tumor of bone; Giant cells; Kyste anévrysmal; Tumeur brune; Tumeur à cellules géantes des os.
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