Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

Biochemistry. 2018 Apr 10;57(14):2059-2060. doi: 10.1021/acs.biochem.8b00307. Epub 2018 Mar 27.

Authors

Hengrui Liu¹, Stuart L Schreiber^{2

3}, Brent R Stockwell^{1

4}

Affiliations

¹ Department of Chemistry , Columbia University , New York , New York 10027 , United States.
² Department of Chemistry and Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States.
³ Broad Institute , Cambridge , Massachusetts 02142 , United States.
⁴ Department of Biological Sciences , Columbia University , 550 West 120th Street, MC 4846 , New York , New York 10027 , United States.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Drug Delivery Systems / methods*
Enzyme Inhibitors / therapeutic use*
Glutathione Peroxidase* / antagonists & inhibitors
Glutathione Peroxidase* / genetics
Glutathione Peroxidase* / metabolism
Humans
Lipid Peroxidation / drug effects*
Lipid Peroxides / metabolism*
Neoplasms* / drug therapy
Neoplasms* / enzymology
Neoplasms* / genetics
Phospholipid Hydroperoxide Glutathione Peroxidase

Substances

Enzyme Inhibitors
Lipid Peroxides
Phospholipid Hydroperoxide Glutathione Peroxidase
Glutathione Peroxidase

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