Abstract
Advances in nanotechnology have led to the design of multifunctional nanoparticles capable of cellular imaging, targeted drug delivery, and diagnostics for early cancer detection. We synthesized poly(lactic-co-glycolic acid) nanoparticles encapsulating a model radiosensitizing drug docetaxel accomplishing localized in situ delivery of the sensitizer to the tumor site. The synthesized nanoparticles have been characterized for their physicochemical properties. The in vitro cytotoxicity of drug-loaded nanoparticles has been studied on human tongue carcinoma cell line SCC-9 (ATCC-CRL-1629).
Keywords:
PLGA nanoformulation; docetaxel.
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Chemistry Techniques, Synthetic
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Docetaxel
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Drug Carriers / chemical synthesis
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Drug Carriers / chemistry
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Drug Carriers / pharmacology
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Drug Delivery Systems / methods
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Humans
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Lactic Acid / chemistry
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Mouth Neoplasms / drug therapy*
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Nanoconjugates / chemistry*
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Nanoparticles / chemistry*
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Polyglycolic Acid / chemistry
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Polylactic Acid-Polyglycolic Acid Copolymer
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Taxoids / administration & dosage*
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Taxoids / chemistry
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Taxoids / pharmacology
Substances
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Antineoplastic Agents
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Drug Carriers
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Nanoconjugates
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Taxoids
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Docetaxel
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid