Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

Cong-Cong Liu; Zhen-Zhen Zhang; Yan-Yan Feng; Qian-Qun Gu; De-Hai Li; Tian-Jiao Zhu

doi:10.1080/14786419.2018.1455045

Secondary metabolites from Antarctic marine-derived fungus Penicillium crustosum HDN153086

Nat Prod Res. 2019 Feb;33(3):414-419. doi: 10.1080/14786419.2018.1455045. Epub 2018 Mar 30.

Authors

Cong-Cong Liu¹, Zhen-Zhen Zhang¹, Yan-Yan Feng¹, Qian-Qun Gu¹, De-Hai Li^{1

2}, Tian-Jiao Zhu^{1

2}

Affiliations

¹ a Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China , Qingdao , P. R. China.
² b Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology , Qingdao , P. R. China.

PMID: 29600717
DOI: 10.1080/14786419.2018.1455045

Abstract

A new polyene compound (1) and a new diketopiperazine (2), as well as three known compounds (3-5), were isolated from the Antarctic marine-derived fungus Penicillium crustosum HDN153086. The structures of 1-5 were deduced based on MS, NMR and TD-DFT calculations of specific ECD spectra. These compounds were evaluated for their cytotoxic activities against K562 cell line and only compound 2 exhibited cytotoxicity against K562 cell, with IC₅₀ value of 12.7 μM.

Keywords: Antarctic; Secondary metabolites; cytotoxicity; marine-derived fungus.

MeSH terms

Antarctic Regions
Aquatic Organisms
Diketopiperazines / chemistry
Diketopiperazines / isolation & purification*
Diketopiperazines / pharmacology
Drug Screening Assays, Antitumor
Humans
K562 Cells
Magnetic Resonance Spectroscopy
Molecular Structure
Penicillium / chemistry
Penicillium / metabolism*
Polyenes / chemistry
Polyenes / isolation & purification*
Polyenes / pharmacology

Substances

Diketopiperazines
Polyenes