Role of altered immune cells in liver diseases: a review

Braira Wahid; Amjad Ali; Shazia Rafique; Komal Saleem; Muhammad Waqar; Muhammad Wasim; Muhammad Idrees

doi:10.1016/j.gastrohep.2018.01.014

Role of altered immune cells in liver diseases: a review

Gastroenterol Hepatol. 2018 Jun-Jul;41(6):377-388. doi: 10.1016/j.gastrohep.2018.01.014. Epub 2018 Mar 28.

[Article in English, Spanish]

Authors

Braira Wahid¹, Amjad Ali², Shazia Rafique², Komal Saleem¹, Muhammad Waqar¹, Muhammad Wasim³, Muhammad Idrees⁴

Affiliations

¹ Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan; Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan.
² Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan.
³ Department of Medicine, Khyber Teaching Hospital Peshawar KPK, Pakistan.
⁴ Centre for Applied Molecular Biology (CAMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan; Genome Centre for Molecular Based Diagnostics and Research, Al-Sudais Plaza Abdalian Cooperative Society, Lahore, Pakistan; Department of Medicine, Khyber Teaching Hospital Peshawar KPK, Pakistan; Division of Molecular Virology and Diagnostics Center of Excellence in Molecular Biology (CEMB), 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan; Vice Chancellor Hazara University Mansehra, Pakistan. Electronic address: [email protected].

PMID: 29605453
DOI: 10.1016/j.gastrohep.2018.01.014

Abstract

Immune cells play an important role in controlling liver tumorigenesis, viral hepatitis, liver fibrosis and contribute to pathogenesis of liver inflammation and injury. Accumulating evidence suggests the effectiveness of natural killer (NK) cells and Kupffer cells (KCs) against viral hepatitis, hepatocellular damage, liver fibrosis, and carcinogenesis. Activation of natural killer cells provides a novel therapeutic strategy to cure liver related diseases. This review discusses the emerging roles of immune cells in liver disorders and it will provide baseline data to scientists to design better therapies for treatment.

Keywords: Cirrhosis; Cirrosis; Células NK; Células de Kupffer; Células dendríticas; Dendritic cells; Hepatic stellate cells; Hígado; Liver; NK Cells.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Immune System / cytology*
Immune System / immunology*
Liver Diseases / immunology*