Single-Cell Transcriptomic Analysis of Tumor Heterogeneity

Trends Cancer. 2018 Apr;4(4):264-268. doi: 10.1016/j.trecan.2018.02.003. Epub 2018 Mar 9.

Abstract

Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. In the future these technologies might inform the selection of targeted combination therapies and enrollment criteria for clinical trials.

Publication types

  • Review

MeSH terms

  • Combined Modality Therapy / methods
  • Computational Biology / methods*
  • Gene Expression Profiling / methods*
  • High-Throughput Nucleotide Sequencing*
  • Humans
  • Molecular Targeted Therapy / methods
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Neoplasms / therapy
  • Precision Medicine / methods
  • RNA / genetics
  • Sequence Analysis, RNA
  • Single-Cell Analysis / methods*

Substances

  • RNA