New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus

Yi-Rui Wang; Bao-Song Cui; Shao-Wei Han; Shuai Li

doi:10.1080/10286020.2018.1457653

New dammarane triterpenoid saponins from the leaves of Cyclocarya paliurus

J Asian Nat Prod Res. 2018 Nov;20(11):1019-1027. doi: 10.1080/10286020.2018.1457653. Epub 2018 Apr 3.

Authors

Yi-Rui Wang¹, Bao-Song Cui¹, Shao-Wei Han¹, Shuai Li¹

Affiliation

¹ a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica , Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.

PMID: 29614867
DOI: 10.1080/10286020.2018.1457653

Abstract

Three new dammarane triterpenoid saponins, cyclocariosides O-Q (1-3), were isolated from the ethanolic extracts of the leaves of Cyclocarya paliurus. The structures of these compounds were elucidated by spectroscopic methods.

Keywords: Juglandaceae; cyclocarioside O; cyclocarioside Q; dammarane triterpenoid saponins.

MeSH terms

Acetaminophen / toxicity
Analgesics / toxicity
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / pharmacology
Cell Line, Tumor
Chemical and Drug Induced Liver Injury / prevention & control
Humans
Juglandaceae / chemistry*
Mice
Molecular Structure
Plant Leaves / chemistry*
RAW 264.7 Cells
Saponins / chemistry*
Triterpenes / chemistry*
Tumor Necrosis Factor-alpha / antagonists & inhibitors

Substances

Analgesics
Antineoplastic Agents, Phytogenic
Saponins
Triterpenes
Tumor Necrosis Factor-alpha
Acetaminophen