Mitochondrial mutations associated with hearing and balance disorders

Iman Ibrahim; Mev Dominguez-Valentin; Bernard Segal; Anthony Zeitouni; Sabrina Daniela da Silva

doi:10.1016/j.mrfmmm.2018.03.003

Mitochondrial mutations associated with hearing and balance disorders

Mutat Res. 2018 Jul:810:39-44. doi: 10.1016/j.mrfmmm.2018.03.003. Epub 2018 Mar 10.

Authors

Iman Ibrahim¹, Mev Dominguez-Valentin², Bernard Segal³, Anthony Zeitouni⁴, Sabrina Daniela da Silva⁵

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, McGill University, Canada. Electronic address: [email protected].
² Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway. Electronic address: [email protected].
³ Department of Otolaryngology-Head and Neck Surgery, McGill University, Canada. Electronic address: [email protected].
⁴ Department of Otolaryngology-Head and Neck Surgery, McGill University, Canada. Electronic address: [email protected].
⁵ Department of Otolaryngology-Head and Neck Surgery, McGill University, Canada. Electronic address: [email protected].

PMID: 29615272
DOI: 10.1016/j.mrfmmm.2018.03.003

Abstract

Hearing and balance disorders are related to the inner ear and are among the major cause of falls in older adults. Hearing loss that commonly occurs with aging (aka presbyacusis) can result from noise exposure, smoking, ototoxic drugs and genetic factors such as mutations in nuclear and mitochondrial genes. Mutations in mitochondrial DNA (mtDNA) have been reported to play an important role in cell function by providing energy, as well as, cell death (apoptosis). This study aims to systematically review mitochondrial mutations associated with presbyacusis and suggests preventive measurements to improve the quality of life in older adults.

Keywords: Balance disorders; Hearing loss; Mitochondrial mutation; Older adults; Presbyacusis; Presbyastasis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA, Mitochondrial / genetics*
Ear, Inner / pathology*
Hearing Loss / genetics*
Humans
Mitochondria / genetics*
Postural Balance / genetics*
Presbycusis / genetics*
Sensation Disorders / genetics*

Substances

DNA, Mitochondrial

Grants and funding

CIHR/Canada