Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients

Matej Skorvanek; Pablo Martinez-Martin; Norbert Kovacs; Ivan Zezula; Mayela Rodriguez-Violante; Jean-Christophe Corvol; Pille Taba; Klaus Seppi; Oleg Levin; Anette Schrag; Iciar Aviles-Olmos; Mario Alvarez-Sanchez; Tomoko Arakaki; Zsuzsanna Aschermann; Eve Benchetrit; Charline Benoit; Alberto Bergareche-Yarza; Amin Cervantes-Arriaga; Anabel Chade; Florence Cormier; Veronika Datieva; David A Gallagher; Nelida Garretto; Zuzana Gdovinova; Oscar Gershanik; Milan Grofik; Vladimir Han; Liis Kadastik-Eerme; Monica M Kurtis; Graziella Mangone; Juan Carlos Martinez-Castrillo; Amelia Mendoza-Rodriguez; Michal Minar; Henry P Moore; Mari Muldmaa; Christoph Mueller; Bernadette Pinter; Werner Poewe; Karin Rallmann; Eva Reiter; Carmen Rodriguez-Blazquez; Carlos Singer; Peter Valkovic; Christopher G Goetz; Glenn T Stebbins

doi:10.1016/j.parkreldis.2018.03.027

Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients

Parkinsonism Relat Disord. 2018 Jul:52:83-89. doi: 10.1016/j.parkreldis.2018.03.027. Epub 2018 Mar 28.

Authors

Matej Skorvanek¹, Pablo Martinez-Martin², Norbert Kovacs³, Ivan Zezula⁴, Mayela Rodriguez-Violante⁵, Jean-Christophe Corvol⁶, Pille Taba⁷, Klaus Seppi⁸, Oleg Levin⁹, Anette Schrag¹⁰, Iciar Aviles-Olmos¹¹, Mario Alvarez-Sanchez¹², Tomoko Arakaki¹³, Zsuzsanna Aschermann¹⁴, Eve Benchetrit⁶, Charline Benoit⁶, Alberto Bergareche-Yarza¹⁵, Amin Cervantes-Arriaga¹⁶, Anabel Chade¹⁷, Florence Cormier⁶, Veronika Datieva⁹, David A Gallagher¹⁸, Nelida Garretto¹³, Zuzana Gdovinova¹⁹, Oscar Gershanik¹⁷, Milan Grofik²⁰, Vladimir Han¹⁹, Liis Kadastik-Eerme⁷, Monica M Kurtis²¹, Graziella Mangone⁶, Juan Carlos Martinez-Castrillo²², Amelia Mendoza-Rodriguez²³, Michal Minar²⁴, Henry P Moore²⁵, Mari Muldmaa²⁶, Christoph Mueller⁸, Bernadette Pinter⁸, Werner Poewe⁸, Karin Rallmann⁷, Eva Reiter⁸, Carmen Rodriguez-Blazquez², Carlos Singer²⁵, Peter Valkovic²⁴, Christopher G Goetz²⁷, Glenn T Stebbins²⁷

Affiliations

¹ Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital L. Pasteur, Kosice, Slovak Republic; Centre of Experimental, Translational and Clinical Medicine, Technology and Innovation Park, P. J. Safarik University, Kosice, Slovak Republic. Electronic address: [email protected].
² National Center of Epidemiology and CIBERNED, Carlos III Institute of Health, Madrid, Spain.
³ Dept. of Neurology, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
⁴ Inst. of Mathematics, P. J. Safarik University, Kosice, Slovak Republic.
⁵ Movement Disorders Unit, Instituto Nacional de Neurologia y Neurocirugia, Mexico DF, Mexico.
⁶ Sorbonne Universités, UPMC Univ Paris 06, INSERM UMRS_1127, CIC_1422, CNRS UMR_7225, AP-HP, ICM, Hôpital Pitié-Salpêtrière, Département des maladies du système nerveux, F-75013, Paris, France.
⁷ Dept. of Neurology and Neurosurgery, University of Tartu, Tartu, Estonia.
⁸ Dep. of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
⁹ Dept. of Neurology, Russian Medical Academy of Postgraduate Education, Moscow, Russia.
¹⁰ Dept. of Clinical Neuroscience, UCL Institute of Neurology, London, UK.
¹¹ Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK.
¹² Dept. of Movement Disorders and Neurodegeneration, CIREN, La Habana, Cuba.
¹³ Dept. of Neurology, Hospital Ramos Mejia, Buenos Aires, Argentina.
¹⁴ Dept. of Neurology, University of Pécs, Pécs, Hungary.
¹⁵ Dept. of Neurology, Donostia Hospital, Biodonostia Institute and CIBERNED, Sen Sebastian, Spain.
¹⁶ Clinical Neurodegenerative Diseases Research Unit, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
¹⁷ Movement Disorders Unit, Institute of Neurosciences, Favaloro University, INECO, Buenos Aires, Argentina.
¹⁸ Barts Health NHS Trust, The Royal London Hospital, London, UK.
¹⁹ Dept. of Neurology, P. J. Safarik University, Kosice, Slovak Republic; Dept. of Neurology, University Hospital L. Pasteur, Kosice, Slovak Republic.
²⁰ Dept. of Neurology, Comenius University, Martin, Slovak Republic.
²¹ Movement Disorders Program, Dept. of Neurology, Hospital Ruber Internacional, Madrid, Spain.
²² Movement Disorders Unit, Dept. of Neurology, Hospital Ramon y Cajal, IRYCIS, Madrid, Spain.
²³ Department of Neurology, Complejo Asistencial de Segovia, Segovia, Spain.
²⁴ 2nd Dept. of Neurology, Faculty of Medicine, Comenius University, Bratislava, Slovak Republic.
²⁵ Dept. of Neurology, University of Miami, Miami, FL, USA.
²⁶ Dept. of Neurology, North Estonian Medical Center, Tallinn, Estonia.
²⁷ Dept. of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.

PMID: 29625875
DOI: 10.1016/j.parkreldis.2018.03.027

Abstract

Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients.

Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items.

Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue.

Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.

Keywords: Activities of daily living; MDS-UPDRS; Non-motor symptoms; Parkinson's disease; Quality of Life.

Publication types

Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Parkinson Disease / diagnosis*
Psychiatric Status Rating Scales*
Quality of Life*
Regression Analysis
Severity of Illness Index*

Grants and funding

G-0508/PUK_/Parkinson's UK/United Kingdom