Effects of the -141C insertion/deletion polymorphism in the dopamine D2 receptor gene on the dopamine system in the striatum in patients with schizophrenia

Psychiatry Res. 2018 Jun:264:116-118. doi: 10.1016/j.psychres.2018.03.029. Epub 2018 Mar 29.

Abstract

The relationships between -141C insertion/deletion (Ins/Del) polymorphisms in the dopamine D2 receptor gene and the two dopamine system integrators, i.e., dopamine- and cAMP-regulated phosphoprotein of molecular weight 32 kDa (DARPP-32) and calcineurin (CaN), are still unclear. In this study, we assessed the effect of this polymorphism on DARPP-32 and CaN protein expression in the postmortem striatum of patients with schizophrenia and control individuals. The expression levels of truncated DARPP and CaN were lower in Del allele carriers. These findings provide important insights into the mechanism by which this genotype could result in a poor response to antipsychotic drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Autopsy
  • Calcineurin / genetics
  • Dopamine / genetics*
  • Dopamine and cAMP-Regulated Phosphoprotein 32 / genetics
  • Female
  • Genotype
  • Humans
  • INDEL Mutation / genetics*
  • Male
  • Neostriatum
  • Polymorphism, Genetic / genetics*
  • Receptors, Dopamine D2 / genetics*
  • Schizophrenia / genetics*

Substances

  • Dopamine and cAMP-Regulated Phosphoprotein 32
  • PPP1R1B protein, human
  • Receptors, Dopamine D2
  • Calcineurin
  • Dopamine