Triangular gold nanoparticles modify shell characteristics and increase antioxidant enzyme activities in the clam Ruditapes decussatus

Biomarkers. 2018 Sep;23(6):580-588. doi: 10.1080/1354750X.2018.1463565. Epub 2018 Apr 19.

Abstract

Context: Nanoparticles may cause adverse environmental effects but there is limited information on their interactions with marine organisms.

Objective: Our aim was to examine the effects of triangular gold nanoparticles (Tr-Au NPs) on the clam, Ruditapes decussatus.

Materials and methods: Clams were exposed to Tr-Au1 = 5 µg/L and Tr-Au2 = 10 µg/L for 2 and 7 days. Effects on shell structure were investigated. Superoxide dismutase (SOD), catalase (CAT), glutathione transferase (GST) activities, protein carbonyl levels and malondialdehyde content were used to assess biochemical status.

Results: Transmission electron microscopy (TEM) and electron dispersive X-ray microanalysis (EDX) showed that Tr-Au NPs modified shell structure and morphology. Tr-Au NPs size increased forming aggregate particles. Tr-Au NPs increased SOD, CAT and GST activities in gill and digestive gland in a concentration- and time-dependent manner indicating defence against oxidative stress. Enhanced lipid peroxidation and protein carbonyl levels confirmed oxidative stress.

Conclusion: Tr-Au NPs cause oxidative stress and affect shell structure of clams. These findings may have relevance to other marine species.

Keywords: Oxidative stress; biomarkers; biomonitoring; bivalve.

MeSH terms

  • Animal Shells / drug effects
  • Animal Shells / metabolism*
  • Animal Shells / ultrastructure
  • Animals
  • Antioxidants / metabolism
  • Biomarkers / metabolism
  • Bivalvia / anatomy & histology*
  • Bivalvia / drug effects
  • Bivalvia / metabolism
  • Catalase / metabolism
  • Electron Probe Microanalysis
  • Enzymes / metabolism*
  • Gills / drug effects
  • Gills / metabolism
  • Glutathione Peroxidase / metabolism
  • Glutathione Transferase / metabolism
  • Gold / administration & dosage
  • Gold / chemistry*
  • Malondialdehyde / metabolism
  • Metal Nanoparticles / administration & dosage
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Microscopy, Electron, Transmission
  • Superoxide Dismutase / metabolism

Substances

  • Antioxidants
  • Biomarkers
  • Enzymes
  • Malondialdehyde
  • Gold
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Transferase