Glucose, insulin, and the carotid body chemoreceptors in humans

Physiol Genomics. 2018 Jul 1;50(7):504-509. doi: 10.1152/physiolgenomics.00032.2018. Epub 2018 Apr 13.

Abstract

Known primarily for its oxygen-sensing capabilities, the carotid body chemoreceptors have recently been implicated, primarily by work in animal models, in the pathophysiology of a number of metabolic conditions. The research presented in this brief review highlights translational work conducted at the Mayo Clinic between 2010 and 2017 in healthy humans and discusses key areas for future work in disease populations.

Keywords: carotid body; chemoreflex; humans; hypoxic ventilatory response.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Carotid Body / cytology
  • Carotid Body / metabolism*
  • Chemoreceptor Cells / metabolism*
  • Glucose / metabolism*
  • Humans
  • Hypoxia
  • Insulin / metabolism*
  • Oxygen / metabolism
  • Translational Research, Biomedical / methods
  • Translational Research, Biomedical / trends

Substances

  • Insulin
  • Glucose
  • Oxygen