Radium-223 in the treatment of bone metastasis in patients with castration-resistant prostate cancer. Review and procedure

Rev Esp Med Nucl Imagen Mol (Engl Ed). 2018 Sep-Oct;37(5):330-337. doi: 10.1016/j.remn.2018.02.007. Epub 2018 Apr 13.
[Article in English, Spanish]

Abstract

Bone metastatic disease is the main cause of morbidity / mortality in patients with prostate cancer, presenting frequently as bone pain, pathological fractures or spinal cord compression, which requires early and timely therapy. Although, for the moment, the therapeutic window for its use has not been definitively established, radium-223 (223Ra), an alpha particle emitter, has proved to be an effective therapeutic tool, pre or post-chemotherapy, in patients with castration-resistant prostate cancer with symptomatic bone metastases and absence of visceral metastases, significantly modifying the prognosis of the disease. It is therefore imperative to define the ideal scenarios and the correct protocol for the use of this therapy and thus offer the greatest possible clinical benefit to the patient.

Keywords: (223)Ra; Bone metastases; Castration-resistant prostate cancer; Cáncer de próstata resistente a castración; Metástasis óseas; Radionuclide therapy; Terapia radiometabólica.

Publication types

  • Review

MeSH terms

  • Bone Neoplasms / radiotherapy*
  • Bone Neoplasms / secondary
  • Humans
  • Male
  • Prostatic Neoplasms, Castration-Resistant / pathology*
  • Radiotherapy Dosage
  • Radium / therapeutic use*

Substances

  • Radium-223
  • Radium