Inorganic hydrogen polysulfides: chemistry, chemical biology and detection

Br J Pharmacol. 2019 Feb;176(4):616-627. doi: 10.1111/bph.14330. Epub 2018 May 14.

Abstract

Recent studies suggest that inorganic hydrogen polysulfides (H2 Sn , n ≥ 2) play important regulatory roles in redox biology. Modulation of their cellular levels could have potential therapeutic value. This review article focuses on our current understanding of the biosynthesis, biofunctions, fundamental physical/chemical properties, detection methods and delivery techniques of H2 Sn . LINKED ARTICLES: This article is part of a themed section on Chemical Biology of Reactive Sulfur Species. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.4/issuetoc.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Fluorescent Dyes
  • Humans
  • Sulfides / chemistry
  • Sulfides / metabolism*

Substances

  • Fluorescent Dyes
  • Sulfides
  • polysulfide