Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma

Christopher J Ricketts; W Marston Linehan

doi:10.1016/j.cell.2018.03.077

Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma

Cell. 2018 Apr 19;173(3):540-542. doi: 10.1016/j.cell.2018.03.077.

Authors

Christopher J Ricketts¹, W Marston Linehan²

Affiliations

¹ Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
² Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Electronic address: [email protected].

PMID: 29677504
DOI: 10.1016/j.cell.2018.03.077

Abstract

Extensive multi-regional whole-genome and -exome sequencing performed in tumors from patients with localized, as well as metastatic, clear cell renal cell carcinoma provides a comprehensive description of the tumor origin, intratumoral heterogeneity, evolution, and route to metastasis, laying the foundation for the development of precision clinical management.

Multi-regional Sequencing Elucidates the Evolution of Clear Cell Renal Cell Carcinoma

Authors

Affiliations

Abstract

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