Thromboxane A2 facilitates IL-17A production from Vγ4+ γδ T cells and promotes psoriatic dermatitis in mice

J Allergy Clin Immunol. 2018 Aug;142(2):680-683.e2. doi: 10.1016/j.jaci.2018.01.054. Epub 2018 Apr 17.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dermatitis / immunology*
  • Disease Models, Animal
  • Humans
  • Imiquimod
  • Interleukin-17 / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Psoriasis / immunology*
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism
  • Receptors, G-Protein-Coupled / metabolism
  • Receptors, Thromboxane A2, Prostaglandin H2 / genetics
  • Receptors, Thromboxane A2, Prostaglandin H2 / metabolism
  • T-Lymphocytes / immunology*
  • Thromboxane A2 / metabolism*
  • Thromboxane-A Synthase / genetics
  • Thromboxane-A Synthase / metabolism

Substances

  • Interleukin-17
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, G-Protein-Coupled
  • Receptors, Thromboxane A2, Prostaglandin H2
  • Thromboxane A2
  • Thromboxane-A Synthase
  • Imiquimod