CRISPR genetic screens to discover host-virus interactions

Curr Opin Virol. 2018 Apr:29:87-100. doi: 10.1016/j.coviro.2018.03.007.

Abstract

Viruses impose an immense burden on human health. With the goal of treating and preventing viral infections, researchers have carried out genetic screens to improve our understanding of viral dependencies and identify potential anti-viral strategies. The emergence of CRISPR genetic screening tools has facilitated this effort by enabling host-virus screens to be undertaken in a more versatile and fidelitous manner than previously possible. Here we review the growing number of CRISPR screens which continue to increase our understanding of host-virus interactions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CRISPR-Cas Systems*
  • Clustered Regularly Interspaced Short Palindromic Repeats
  • Flavivirus / genetics
  • Flavivirus / metabolism
  • Genetic Testing*
  • Host-Pathogen Interactions*
  • Humans
  • Receptors, Virus / metabolism
  • Virus Diseases / virology*
  • Viruses / genetics*
  • Workflow

Substances

  • Receptors, Virus