Along with the development of periodontal medicine, there is a growing number of evidence showing that periodontitis could influence systemic health. Periodontitis is a chronic inflammatory disease caused by microbial infection mediated by dental plaque. Periodontal pathogenic microorganisms and its toxic products can disseminate through the blood stream or may cause the host immune response, which may lead to pathological changes of cerebral vessels and brain tissues to establish connection with Alzheimer's disease (AD). AD is a progressive neurodegenerative disease characterized by progressive memory loss, language and cognitive dysfunction. This article reviewed the association between chronic periodontitis and AD.
随着牙周医学的发展，关于慢性牙周炎对全身健康影响的证据越来越多。牙周炎是牙菌斑微生物感染引发的慢性炎症性疾病，其致病微生物及毒性产物通过血液播散、引发宿主免疫应答等可能导致脑血管与脑组织的病理改变，从而与阿尔茨海默病相关。阿尔茨海默病是渐进性中枢神经系统的退行性疾病，临床上以进行性记忆缺失、语言及认知功能障碍等为主要表现，严重影响患者的生活质量。本文就慢性牙周炎与阿尔茨海默病之间的关系作一综述。.
Keywords: Alzheimer's disease; Inflammation; Periodontitis; Periodontopathic microorganisms.