Metabonomics is an emerging branch of science for the study of endogenous small molecule metabolites in organisms, which plays an important role in evaluatingthediagnosis and treatment of male infertility by exploring the metabolites of body fluids, cells and tissues. With its advantages ofmass information, noninvasiveness, and celerity, metabonomics will be widely applied to clinical researches in the future. This review introducesmetabonomics and its analytical techniques and data processing procedures,its latest application in the studies of the etiology, diagnosis and the treatment of male infertility, and the prospect of its future application in the researches of male reproduction.
代谢组学是研究生物体内源性小分子代谢物的新兴学科。代谢组学通过对体液、细胞及组织的研究，在男性不育疗效评价中发挥着重要作用。 这种高信息量、无创、快速的研究技术进入临床应用将成为未来的发展趋势。本文介绍了代谢组学及其分析技术和数据处理过程，并介绍了代谢组学对男性不育有害物质暴露、生物标志物和药物治疗等的研究，对其在男性不育病因探究和诊疗中的最新研究进展进行了综述，最后提出代谢组学在男性生殖领域的研究前景。.
Keywords: analytical technique; infertility; male; metabonomics.