To Scar or Not to Scar

Aarti Narang; Binhai Zheng

doi:10.1016/j.molmed.2018.04.007

To Scar or Not to Scar

Trends Mol Med. 2018 Jun;24(6):522-524. doi: 10.1016/j.molmed.2018.04.007. Epub 2018 May 2.

Authors

Aarti Narang¹, Binhai Zheng²

Affiliations

¹ Department of Neuroscience, University of California San Diego, La Jolla, California, USA.
² Department of Neuroscience, University of California San Diego, La Jolla, California, USA. Electronic address: [email protected].

Abstract

A recent study indicates that reducing fibrotic scarring by genetically abrogating the proliferation of type A pericytes promotes axon regeneration and functional recovery after spinal cord injury. Questions remain regarding the identity of the cells being manipulated and the balance between the beneficial and detrimental effects of fibrotic scarring.

Keywords: astrocytic scar; axon regeneration; fibrotic scar; functional recovery; spinal cord injury.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cicatrix*
Humans
Nerve Regeneration
Pericytes*
Recovery of Function
Spinal Cord Injuries

Abstract

Publication types

MeSH terms

Grants and funding