Vaccinating with Stem Cells to Stop Cancer

Yared Hailemichael; Manisha Singh; Willem Overwijk

doi:10.1016/j.molmed.2018.04.006

Vaccinating with Stem Cells to Stop Cancer

Trends Mol Med. 2018 Jun;24(6):524-526. doi: 10.1016/j.molmed.2018.04.006. Epub 2018 May 3.

Authors

Yared Hailemichael¹, Manisha Singh¹, Willem Overwijk²

Affiliations

¹ Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; These authors contributed equally.
² Department of Melanoma Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA. Electronic address: [email protected].

PMID: 29731352
DOI: 10.1016/j.molmed.2018.04.006

Abstract

In a recent study, Kooreman and colleagues identify a set of genes expressed in both induced pluripotent stem cells (iPSCs) and cancer cells. Vaccination of mice with iPSCs induces prophylactic and therapeutic anticancer immunity to shared antigens, opening a possible avenue towards rapid generation of iPSC-based, personalized cancer vaccines.

Publication types

Comment

MeSH terms

Animals
Cancer Vaccines*
Induced Pluripotent Stem Cells*
Mice
Neoplasms

Substances

Cancer Vaccines

Grants and funding

R41 CA203456/CA/NCI NIH HHS/United States