Interaction at a distance between lambda repressors disrupts gene activation

A Hochschild; M Ptashne

doi:10.1038/336353a0

Interaction at a distance between lambda repressors disrupts gene activation

Nature. 1988 Nov 24;336(6197):353-7. doi: 10.1038/336353a0.

Authors

A Hochschild¹, M Ptashne

Affiliation

¹ Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, Massachusetts 02138.

PMID: 2973565
DOI: 10.1038/336353a0

Abstract

The lambda repressor is an activator as well as a repressor of transcription. The activation function is blocked by interaction with another lambda repressor molecule bound upstream on the same DNA molecule. This example of negative control at a distance involves formation of a DNA loop.

MeSH terms

Bacteriophage lambda / genetics*
Gene Expression Regulation*
Mutation
Operon
Promoter Regions, Genetic
Repressor Proteins / physiology*
Transcription Factors / physiology*
Transcriptional Activation

Substances

Repressor Proteins
Transcription Factors