Lack of influence of low-dose acetylsalicylic acid (100 mg daily) on platelet survival time, beta-thromboglobulin and platelet factor 4 in patients with peripheral arterial occlusive disease

Thromb Res. 1988 Nov 1;52(3):219-26. doi: 10.1016/0049-3848(88)90081-3.

Abstract

In this study we investigated the influence of low-dose (100 mg daily) acetylsalicylic acid (ASA) on 111-In-platelet survival time (PST) and on plasma levels of beta-thromboglobulin (beta-TG) and platelet factor 4 (PF 4) in 30 patients (median age: 60 years) with arteriographically proven peripheral arterial occlusive disease in a chronic stable phase. We observed no significant changes of PST during therapy with ASA (weighted mean: 169.8----166 [median] hours; multiple hit: 168.3----170.6 hours), and also the plasma levels of beta-TG (median: 31.8----32.3 ng/ml) and of PF 4 (3.6----3.9 ng/ml) remained unchanged.

MeSH terms

  • Adult
  • Aged
  • Arterial Occlusive Diseases / blood*
  • Arterial Occlusive Diseases / drug therapy
  • Aspirin / administration & dosage*
  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Cell Survival / drug effects*
  • Drug Administration Schedule
  • Female
  • Humans
  • Indium Radioisotopes
  • Male
  • Middle Aged
  • Models, Biological
  • Platelet Factor 4 / metabolism*
  • Platelet Transfusion
  • beta-Thromboglobulin / metabolism*

Substances

  • Indium Radioisotopes
  • beta-Thromboglobulin
  • Platelet Factor 4
  • Aspirin